Description Trazodone is used to treat depression. It is thought to work by increasing the activity of serotonin in the brain. Trazodone is an antidepressant. This medicine is available only with your doctor's prescription. Trazodone is an antidepressant medication [21] used to treat major depressive disorder, anxiety disorders, and insomnia. [21] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. [22][23] The medication is taken orally. [21] Common side effects include dry mouth, feeling faint, vomiting, and headache. [21] More serious side effects may include. Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance. NHS medicines information on trazodone – what it's used for, side effects, dosage and who can take it. Trazodone is an antidepressant often prescribed off-label for sleep. It may be an effective sleep aid with fewer side effects than other options, but it may still pose risks. Learn more. Trazodone is an atypical antidepressant. It's FDA-approved to treat depression in adults, but it isn't a first-choice option. In addition, trazodone is sometimes prescribed off-label for difficulty sleeping (insomnia). This medication is taken by mouth, typically once or a few times a day, depending on your condition. Common side effects of this medication include sleepiness, dry mouth, and. Trazodone is a tetracyclic antidepressant used to treat depression and anxiety disorders. Includes trazodone side effects, interactions and indications. Find patient medical information for Trazodone on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Trazodone is a prescription medication used to treat depression. Learn about side effects, dosages, drug interactions, warnings, and more.